Loginov A S, Matiushin B N, Tkachev V D
Ter Arkh. 1997;69(2):25-7.
It is shown that chronic hepatobiliary pathology is associated with a fall in spontaneous metabolite conjugation related to reduced concentration of hepatic glutathione. There was also enhanced activity of glutathione-dependent enzymes. This indicates progress of compensatory processes associated with mobilization of detoxication phase 2, i.e. stimulation of conjugation processes under depression of cytochrome P-450 system. The authors ascertain high informative value of hepatic glutathione transferase in assessment of disease activity in patients with chronic active hepatitis and hepatic cirrhosis.
研究表明，慢性肝胆疾病与自发代谢物结合能力下降有关，这与肝脏谷胱甘肽浓度降低有关。谷胱甘肽依赖性酶的活性也增强。这表明与解毒第二阶段动员相关的代偿过程在进展，即在细胞色素P-450系统受抑制的情况下刺激结合过程。作者确定了肝谷胱甘肽转移酶在评估慢性活动性肝炎和肝硬化患者疾病活动度方面具有很高的信息价值。
