Ennuyer A, Poncet P, Bataini J P
Ann Otolaryngol Chir Cervicofac. 1977 Sep;94(9):477-84.
This statistical study concerned 218 carcinomas of the laryngeal vestibule and margin treated at the Curie Foundation between 1958 and 1967, by primary cobalt therapy followed when necessary by secondary total laryngectomy. It shows that cobalt therapy alone gives excellent results in early forms (T1 and T2) even in the presence of N1 or N2 nodes. By contrast, the proportion of cures is much lower in T3 and T4 forms. Secondary total laryngectomy was used in only 25 cases out of 127 failures. The postoperative course was often difficult (4 fatal complications and 3 pharyngostomies) but 7 of the patients were cured at 5 years. The use of a surgical technique with minimal trauma and in particular respecting the integrity of the carotid gutters has been associated, in a more recent series, with a notable improvement in the results obtained (one cure out of 2 at 3 years).
这项统计学研究涉及1958年至1967年间在居里基金会接受治疗的218例喉前庭和边缘癌,采用原发性钴治疗,必要时辅以继发性全喉切除术。研究表明,即使存在N1或N2淋巴结,单独使用钴治疗对早期(T1和T2)病例也能取得优异效果。相比之下,T3和T4期病例的治愈率要低得多。在127例治疗失败的病例中,仅25例采用了继发性全喉切除术。术后病程通常很艰难(4例致命并发症和3例咽造口术),但7例患者在5年后治愈。在最近的一组病例中,采用创伤最小的手术技术,特别是保留颈动脉沟的完整性,使治疗效果有了显著改善(2例中有1例在3年后治愈)。