Huober J, Holz F G, Schmid H, Nölle B, Bellmann C, Krastel H, Wallwiener D, Bastert G
Universitäts-Frauenklinik, Heidelberg.
Zentralbl Gynakol. 1997;119(6):278-81.
Paraneoplastic retinopathies are rare paraneoplastic phenomena resulting in retinal degeneration. They occur in association with different tumor types, yet most frequently encountered in small cell carcinoma of the lung. Clinical symptoms may be present before the diagnosis of the underlying malignancy. They are characterized clinically by progressive visual loss with ring scotomas, photopsia and night-blindness. An autoimmune disorder is suggested. In the sera of patients antiretinal antibodies may be detected that are sometimes reactive with the 23 kD retinal antigen recoverin, a photoreceptorprotein. We report on two patients with breast cancer who developed paraneoplastic retinopathy during the course of disease. Immunologic tests showed antiretinal antibodies that were not reactive with the 23 kD retinal antigen recoverin.
副肿瘤性视网膜病变是导致视网膜变性的罕见副肿瘤现象。它们与不同的肿瘤类型相关联，但最常见于肺癌小细胞癌。临床症状可能在潜在恶性肿瘤诊断之前出现。其临床特征为进行性视力丧失伴环形暗点、闪光感和夜盲。提示存在自身免疫性疾病。在患者血清中可检测到抗视网膜抗体，这些抗体有时与光感受器蛋白恢复蛋白（一种23 kD视网膜抗原）发生反应。我们报告了两名乳腺癌患者，她们在疾病过程中发生了副肿瘤性视网膜病变。免疫检测显示抗视网膜抗体与23 kD视网膜抗原恢复蛋白无反应。
