Thomas P, Bergoend H
Ann Dermatol Venereol. 1977 Aug-Sep;104(8-9):513-24.
The authors report the principles of investigating photosensitivity of the skin: objects of testing and some basic practical consideration (doses, laws of irradiance, choice of wavelength in a test). Artificial sources for irradiation are studied. Xenon arc lamp is the most suitable. Two main kinds of device are suitable for routine radiant energy measurement; the thermopile with linear spectral response and the photoelectric cells without linear relationship between wavelength and sensitivity. To delimit the emission of xenon arc, the authors use absorption filters (cut-off type). Irradiation monochromator is indispensable to much dermatological photobiology, especially action spectrum study. Methods of measurement, time course of the response dose response relationship, threshold response and action spectrum of normal and abnormal effects of light on the skin are described. Routine phototesting procedure enclose: minimal erythemal dose, phototest, photopatchtest. Technical study and interpretation are exposed. For the dermatologist, phototesting procedure is necessary for the diagnosis. Mechanism of photosensitivity (phototoxic or photoallergic reaction) and wavelength dependence have to be known for an appropriate treatment.
测试对象及一些基本的实际考量(剂量、辐照规律、测试中波长的选择)。对用于辐照的人工光源进行了研究。氙弧灯是最合适的。有两种主要的设备适用于常规辐射能测量;具有线性光谱响应的热电堆和波长与灵敏度之间无线性关系的光电管。为了界定氙弧灯的发射,作者使用了吸收滤光片(截止型)。辐照单色仪对许多皮肤光生物学研究,尤其是作用光谱研究而言是必不可少的。描述了测量方法、反应的时间进程、剂量反应关系、正常和异常光对皮肤影响的阈值反应及作用光谱。常规光测试程序包括:最小红斑量、光试验、光斑贴试验。阐述了技术研究及解释。对于皮肤科医生而言,光测试程序对诊断是必要的。为了进行恰当的治疗必须了解光敏感性的机制(光毒性或光变应性反应)及波长依赖性。