Armstrong R B, Leach E E, Whitman G, Harber L C, Poh-Fitzpatrick M B
Arch Dermatol. 1985 Apr;121(4):525-8.
A 55-year-old woman developed a dermatitis confined to light-exposed areas while taking quinidine gluconate, warfarin sodium, furosemide, spironolactone, and digoxin after cardiac surgery. Phototesting indicated a normal erythematous response to 290- to 320-nm ultraviolet radiation, but she developed erythema from 6 joules/sq cm of 320- to 400-nm radiation (ultraviolet A [UV-A]), a much lower dose than needed to produce a reaction in normal individuals. Two days after she discontinued quinidine and warfarin, phototesting showed no reaction to as much as 20 joules/sq cm of UV-A. One week after resuming quinidine (but not warfarin), she again reacted to 8 joules/sq cm of UV-A. No reactivity was elicited when the preparation was applied to the skin or injected into the dermis either with or without subsequent UV-A irradiation.
一名55岁女性在心脏手术后服用葡萄糖酸奎尼丁、华法林钠、呋塞米、螺内酯和地高辛时，出现了仅局限于光照部位的皮炎。光试验表明，对290至320纳米的紫外线辐射有正常的红斑反应，但她对320至400纳米辐射（紫外线A [UV-A]）6焦耳/平方厘米的剂量就出现了红斑，这一剂量远低于在正常个体中产生反应所需的剂量。在她停用奎尼丁和华法林两天后，光试验显示对高达20焦耳/平方厘米的UV-A没有反应。在重新服用奎尼丁（但未服用华法林）一周后，她再次对8焦耳/平方厘米的UV-A产生反应。无论有无后续UV-A照射，将该制剂涂抹于皮肤或注射到真皮中均未引发反应。
