Daehlin L, Tønder B, Kapstad L
Department of Surgery, Haukeland Hospital, Bergen, Norway.
Br J Urol. 1997 Sep;80(3):468-71. doi: 10.1046/j.1464-410x.1997.00358.x.
To compare the effects and side-effects of polidocanol and tetracycline when used as sclerosants for testicular hydrocele and epididymal cyst.
Forty-five men (median age 67 years, range 42-81) with 46 hydroceles or epididymal cysts were assessed. After puncture and aspiration, the empty sac was instilled with either polidocanol or tetracycline, assigned randomly. Patients recorded any treatment-associated pain on a visual analogue scale.
At 9 months of follow-up, nine of 17 men were cured after sclerotherapy with polidocanol compared with 17 of 20 men treated with tetracycline (P < 0.05). Tetracycline produced some pain for 3 days after treatment while polidocanol therapy was almost pain-free. Re-instillation should be considered for recurrences. At the follow-up after 35 months, 16 of 18 men treated with polidocanol and 20 of 22 men treated with tetracycline were satisfied with the outcome.
Both polidocanol and tetracycline are useful sclerosants for treating testicular hydrocele and epididymal cyst. We prefer polidocanol as a first choice in older patients because there were few short-term side-effects.
比较聚多卡醇和四环素作为硬化剂用于治疗睾丸鞘膜积液和附睾囊肿的效果及副作用。
对45名患有46个鞘膜积液或附睾囊肿的男性（年龄中位数67岁，范围42 - 81岁）进行评估。穿刺抽液后，将空囊随机注入聚多卡醇或四环素。患者使用视觉模拟评分法记录任何与治疗相关的疼痛情况。
随访9个月时，17名接受聚多卡醇硬化治疗的男性中有9人治愈，而20名接受四环素治疗的男性中有17人治愈（P < 0.05）。四环素治疗后3天会产生一些疼痛，而聚多卡醇治疗几乎无疼痛。复发时应考虑再次注入药物。在35个月的随访中，18名接受聚多卡醇治疗的男性中有16人、22名接受四环素治疗的男性中有20人对治疗结果满意。
聚多卡醇和四环素都是治疗睾丸鞘膜积液和附睾囊肿的有效硬化剂。对于老年患者，我们更倾向首选聚多卡醇，因为其短期副作用较少。
