Wallace S M, Shah V P, Epstein W L, Greenberg J, Riegelman S
Arch Dermatol. 1977 Nov;113(11):1539-42. doi: 10.1001/archderm.113.11.1539.
Penetration and prophylactic activity against Trichophyton mentagrophytes infection of topically applied antifungal agents were studied in human volunteers. The concentration and persistence of drug in the stratum corneum was determined after different treatment schedules and from different vehicles. Measurable levels of griseofulvin, clotrimazole, miconazole nitrate, and thiabendazole remained in the skin four days after discontinuation of topical applications. Griseofulvin, miconazole, and clotrimazole exhibited prophylactic activity against infection by T mentagrophytes spores in a standardized test. Griseofulvin was a significantly better prophylactic agent than either miconazole or clotrimazole.
在人类志愿者中研究了局部应用抗真菌剂对须癣毛癣菌感染的渗透和预防活性。在不同的治疗方案后以及从不同的载体中测定角质层中药物的浓度和持久性。在停止局部应用后四天，皮肤中仍可检测到灰黄霉素、克霉唑、硝酸咪康唑和噻苯达唑的水平。在标准化试验中，灰黄霉素、咪康唑和克霉唑对须癣毛癣菌孢子感染具有预防活性。灰黄霉素作为预防剂明显优于咪康唑或克霉唑。
