Zaias N, Battistini F, Gomez-Urcuyo F, Rojas R F, Ricart R
Cutis. 1978 Aug;22(2):197-9.
A protocol for determining the antifungal efficacy of systemic or topical drugs in tinea pedis is presented. In this study, (1) no patient had concomitant onychomycosis; (2) the clinical types were separated into (a) plantar scaling, (b) intertriginous, and (c) vesicular instep; (3) the soles were treated for three months (time related to the shedding of all stratum corneum); (4) the follow-up period for soles was three months (related to characteristics of the drug and its depot effect on the target area, the horny layer); (5) the final evaluation related to the percentage of patients "clinically and mycologically cured" at the end of the follow-up period. With this protocol, ultramicrosize griseofulvin (Gris-PEG) alone, topical clotrimazole (Lotrimin) alone, and a combination of the two were tested in seventy-three patients with tinea pedis. The results were as follows: for plantar scaling type of tinea pedis, the combination was not better than griseofulvin alone; for intertriginous tinea pedis, the combination was definitely better than griseofulvin alone; and topical 1 percent clotrimazole was much less effective than griseofulvin.
本文介绍了一种用于确定系统性或局部药物对足癣抗真菌疗效的方案。在本研究中，（1）无患者合并甲癣；（2）临床类型分为（a）足底鳞屑型、（b）擦烂型和（c）足背水疱型；（3）足底治疗三个月（与所有角质层脱落时间相关）；（4）足底随访期为三个月（与药物特性及其在靶区域角质层的储库效应相关）；（5）最终评估与随访期结束时“临床和真菌学治愈”患者的百分比有关。采用该方案，对73例足癣患者分别测试了超微粒灰黄霉素（Gris-PEG）单独使用、外用克霉唑（Lotrimin）单独使用以及两者联合使用的效果。结果如下：对于足底鳞屑型足癣，联合用药并不比单独使用灰黄霉素效果好；对于擦烂型足癣，联合用药肯定比单独使用灰黄霉素效果好；外用1%克霉唑的效果远不如灰黄霉素。
