心房利钠肽在体外可预防支气管收缩。
Atrial natriuretic peptide prevents bronchoconstriction in vitro.
作者信息
Subratty A H
机构信息
Health and Medical Sciences Department, Faculty of Science, University of Mauritius, Reduit.
出版信息
Indian J Exp Biol. 1997 Feb;35(2):197-9.
Under in vitro conditions atrial natriuretic peptide (ANP) caused specific relation of bronchoconstriction induced by tosyl arginine methyl ester (TAME) on rat trachea. This supports the hypothesis that ANP is a relaxant of airway as well as vascular smooth muscle and since lung tissue contains ANP and ANP receptors, it is hypothesized that the lungs may be a target organ for ANP. It is concluded that ANP had definite bronchodilating properties on rat trachea mounted in vitro and could be a possible antagonist of TAME.
在体外条件下，心房利钠肽（ANP）引起了对甲苯磺酰精氨酸甲酯（TAME）诱导的大鼠气管支气管收缩的特异性关联。这支持了ANP是气道以及血管平滑肌舒张剂的假说，并且由于肺组织含有ANP和ANP受体，因此推测肺可能是ANP的靶器官。得出的结论是，ANP对体外安装的大鼠气管具有明确的支气管舒张特性，并且可能是TAME的拮抗剂。
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