TAME 是一种强效的非气道平滑肌收缩剂吗？
Is TAME a potent constrictor of non-airway smooth muscles?
作者信息
Subratty A H, Moonsamy J
机构信息
Department of Health and Medical Sciences, Faculty of Science, University of Mauritius, Reduit.
出版信息
Indian J Exp Biol. 1998 Jun;36(6):618-21.
PMID:9731476
Abstract
Under in vitro conditions N-alpha-tosyl L-arginine methyl ester (TAME) induced a concentration dependent contractile response on ileal strips with EC50 of 4.3 x 10(-5) M as compared to acetylcholine which induced sustainable contractions with EC50 of 3.2 x 10(-6) M. The present study is the first to demonstrate that TAME is a potent constrictor of non-airway smooth muscle.
摘要
在体外条件下，N-α-对甲苯磺酰-L-精氨酸甲酯（TAME）对回肠肌条产生浓度依赖性收缩反应，半数有效浓度（EC50）为4.3×10⁻⁵ M，而乙酰胆碱诱导的可持续收缩的EC50为3.2×10⁻⁶ M。本研究首次证明TAME是一种强效的非气道平滑肌收缩剂。
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