Marghescu S, Christophers E, Mayer G
Hautarzt. 1976 Apr;27(4):166-70.
Delayed skin reaction to tuberculin were elicited in 10 healthy persons by patch testing and intracutaneous application of the antigen (Tine-Test). Biopsies revealed basically identical tissue reactions. After intracutaneous injection of the antigen as well as after Tine-testing the changes were solely found in the dermis, while after patch testing dermal and epidermal alterations were prominent. The type of response elicited by the same allergen in man-the so called tuberculin type of the eczematous type-therefore are due to a differential localization of the antigen.
通过斑贴试验和皮内注射抗原（结核菌素试验），在10名健康人身上引发了对结核菌素的迟发性皮肤反应。活检显示组织反应基本相同。皮内注射抗原以及结核菌素试验后，变化仅见于真皮，而斑贴试验后真皮和表皮改变均很明显。因此，同一变应原在人体引发的反应类型——即所谓的结核菌素型或湿疹型——是由于抗原定位不同所致。
