Scannell J P, Pruess D L, Ax H A, Jacoby A, Kellett M, Stempel A
J Antibiot (Tokyo). 1976 Jan;29(1):38-43. doi: 10.7164/antibiotics.29.38.
A novel amino acid, L-2-amino-4-(2-aminoethoxy-)-butanoic acid, was isolated from a fermentation broth of Streptomyces sp. X-11,085. It was shown to be identical with the chemical reduction product of an antimetabolite antibiotic, L-2-amino-4-(2-aminoethoxy)-trans-3-butenoic acid, a co-product in the fermentation. Addition of the title compound to the fermentation led to an enhanced yield of the antimetabolite suggesting that the saturated amino acid serves as a precursor for the antimetabolite.
从链霉菌属X-11085的发酵液中分离出一种新型氨基酸，L-2-氨基-4-(2-氨基乙氧基)-丁酸。结果表明，它与一种抗代谢物抗生素L-2-氨基-4-(2-氨基乙氧基)-反式-3-丁烯酸的化学还原产物相同，后者是发酵中的一种副产物。将标题化合物添加到发酵中可提高抗代谢物的产量，这表明饱和氨基酸是抗代谢物的前体。
