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新型氨基酸去丙基阿拉波辛的分离及其生物活性。

Isolation of dealanylalahopcin, a new amino acid, and its biological activity.

作者信息

Higashide E, Kanamaru T, Fukase H, Horii S

出版信息

J Antibiot (Tokyo). 1985 Mar;38(3):296-301. doi: 10.7164/antibiotics.38.296.

DOI:10.7164/antibiotics.38.296
PMID:4008327
Abstract

A new amino acid, dealanylalahopcin, was isolated from a culture filtrate of Streptomyces albulus subsp. ochragerus; it was also formed by the enzymatic hydrolysis of alahopcin using microbial alpha-amino acid ester hydrolase. The amino acid was obtained as colorless needles and its molecular formula is C6H10N2O5. It showed very weak antibacterial activity against Gram-positive and Gram-negative bacteria, and weak inhibitory activity against the collagen prolylhydroxylase.

摘要

一种新的氨基酸,脱丙氨阿拉霍平,是从白色链霉菌赭黄亚种的培养滤液中分离出来的;它也可通过使用微生物α-氨基酸酯水解酶对阿拉霍平进行酶促水解而形成。该氨基酸呈无色针状,其分子式为C6H10N2O5。它对革兰氏阳性菌和革兰氏阴性菌表现出非常微弱的抗菌活性,对胶原蛋白脯氨酰羟化酶表现出微弱的抑制活性。

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