Riggs B L, Jowsey J, Kelly P J, Hoffman D L, Arnaud C D
J Clin Endocrinol Metab. 1976 Jun;42(6):1139-44. doi: 10.1210/jcem-42-6-1139.
Eighteen patients (17 women and 1 man) with primary osteoporosis were divided into two groups of 9 patients each. Group A received 2.0 to 2.5 g of calcium and 400 units of vitamin D per day orally and was studied before and after short-term (3 to 4 months) treatment; group B received 1.5 to 2.0 g of calcium per day and 50,000 units of vitamin D twice weekly and was studied before, after short-term, and after long-term (1 year) treatment. In group A there was a decrease (P is less than 0.01) in bone-resorbing surfaces (microradiography of bone biopsy samples) after short-term treatment. In group B there was a decrease (P is less than 0.01) in bone-forming and bone-resorbing surfaces after both short-tern and long-term treatment. Fasting-state (morning) serum immunoreactive parathyroid hormone (iPTH) concentrations decreased after short-term treatment (combined data of groups A and B) and after long-term treatment (group B). We conclude that the principal effect of the oral calcium and vitamin D therapy in primary osteoporosis is to decrease bone turnover. The most probable mechanism for this effect on bone is a partial inhibition of PTH secretion.
18例原发性骨质疏松患者（17名女性和1名男性）被分为两组，每组9例。A组患者每天口服2.0至2.5克钙和400单位维生素D，并在短期（3至4个月）治疗前后进行研究；B组患者每天口服1.5至2.0克钙，每周两次，每次50,000单位维生素D，并在短期治疗前、短期治疗后以及长期（1年）治疗后进行研究。A组在短期治疗后，骨吸收表面（骨活检样本的显微放射照相）减少（P<0.01）。B组在短期和长期治疗后，骨形成和骨吸收表面均减少（P<0.01）。短期治疗后（A组和B组的合并数据）以及长期治疗后（B组），空腹状态（早晨）血清免疫反应性甲状旁腺激素（iPTH）浓度均降低。我们得出结论，口服钙和维生素D治疗原发性骨质疏松的主要作用是降低骨转换。这种对骨骼的作用最可能的机制是部分抑制甲状旁腺激素的分泌。
