Poovorawan Y, Vimolkej T, Chongsrisawat V, Theamboonlers A, Chumdermpadetsuk S
Viral Hepatitis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1997 Mar;28(1):154-7.
Hepatitis A virus (HAV) is a health problem in countries where seroepidemiology shows changes from hyperendemicity to intermediate endemicity. Throughout the last decade, we studied, in Bangkok, the seroprevalence of hepatitis A virus antibody (anti-HAV) among adolescents of different age groups. In 1996, 245 serum specimens from children aged between 10 and 19 were tested for anti-HAV by ELISA method. The results were compared to those obtained in 1987 and 1993 from students of the same age and attending the same school. Anti-HAV was detected in 31.4%, 14.6% and 12.7% of school children in the years 1987, 1993 and 1996, respectively. Each year, it was found that an increasing prevalence of anti-HAV was related to an increasing age. From 1987 to 1996, the age specific prevalence of anti-HAV was markedly decreased in younger children. The surveillance of the epidemiological trend of HAV infection is important for implementing preventive measures and for controlling the disease.
在血清流行病学显示从高度地方性流行转变为中度地方性流行的国家，甲型肝炎病毒（HAV）是一个健康问题。在过去十年中，我们在曼谷研究了不同年龄组青少年中甲型肝炎病毒抗体（抗-HAV）的血清流行率。1996年，采用酶联免疫吸附测定（ELISA）法对245份年龄在10至19岁儿童的血清标本进行了抗-HAV检测。将结果与1987年和1993年从同一年龄且就读于同一学校的学生中获得的结果进行比较。1987年、1993年和1996年分别有31.4%、14.6%和12.7%的学童检测到抗-HAV。每年都发现，抗-HAV流行率的上升与年龄增长有关。从1987年到1996年，年幼儿童中抗-HAV的年龄特异性流行率显著下降。监测甲型肝炎病毒感染的流行病学趋势对于实施预防措施和控制该疾病很重要。
