从红藻缘管浒苔中分离得到的细胞毒性氧化鲨烯醇的研究。
Study on cytotoxic oxygenated desmosterols isolated from the red alga Galaxaura marginata.
作者信息
Sheu J H, Huang S Y, Wang G H, Duh C Y
机构信息
Department of Marine Resources, National Sun Yat-Sen University, Kaohsiung, Taiwan, Republic of China.
出版信息
J Nat Prod. 1997 Sep;60(9):900-3. doi: 10.1021/np9701844.
Four novel oxygenated desmosterols, 24 zeta-hydroperoxy-6 beta-hydroxycholesta-4,25-dien-3-one (1), 25-hydroperoxy-6 beta-hydroxycholesta-4,23(E)-dien-3-one (2), 24 zeta-hydroperoxycholesta-4,25-diene-3,6-dione (3), and 25-hydroperoxycholesta-4,23(E)-diene-3,6-dione (4) were isolated from the marine red alga Galaxaura marginata. Steroids 1-4 and three synthetic oxygenated desmosterols 5-7 were shown to exhibit significant cytotoxicity against several cancer cell lines.
从海洋红藻缘管浒苔中分离出四种新型氧化鲨烯醇，即24ζ-氢过氧基-6β-羟基胆甾-4,25-二烯-3-酮（1）、25-氢过氧基-6β-羟基胆甾-4,23（E）-二烯-3-酮（2）、24ζ-氢过氧基胆甾-4,25-二烯-3,6-二酮（3）和25-氢过氧基胆甾-4,23（E）-二烯-3,6-二酮（4）。甾体1-4以及三种合成氧化鲨烯醇5-7对几种癌细胞系显示出显著的细胞毒性。
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