Cahn M D, Tran T, Theur C P, Butler J A
Department of Surgery, University of California, Irvine Medical Center 92668, USA.
Am Surg. 1997 Oct;63(10):858-60.
To determine whether postmenopausal individuals being treated with hormone replacement therapy (HRT) have an increased risk for lesions that predispose to breast cancer, 156 women with benign breast lesions were retrospectively studied. Their ages ranged from 43 to 88. Each patient underwent a breast biopsy from 1991 to 1995. It was determined from chart review whether each of these patients had been treated with HRT. Fifty-seven of these patients had a biopsy finding that predisposed the patient to future breast cancer. The predisposing lesions included sclerosing adenosis, intraductal papilloma, and epithelial hyperplasia with atypia. Of these 57 patients, 36 (63%) were being treated with HRT. Only 30 of the 99 patients (30%) with nonproliferative lesions were treated with HRT (odds ratio, 3.9; P < 0.0005). On the basis of the results of this study, we believe that the use of HRT may promote lesions that predispose to cancer. This suggests that patients treated with HRT require vigilant surveillance by way of examination and mammography.
为了确定接受激素替代疗法（HRT）的绝经后个体患易引发乳腺癌病变的风险是否增加，对156例患有乳腺良性病变的女性进行了回顾性研究。她们的年龄在43岁至88岁之间。从1991年到1995年，每位患者都接受了乳腺活检。通过查阅病历确定这些患者中每一位是否接受过HRT治疗。其中57例患者的活检结果显示其易患未来乳腺癌。易患病变包括硬化性腺病、导管内乳头状瘤和非典型上皮增生。在这57例患者中，36例（63%）正在接受HRT治疗。在99例非增殖性病变患者中，只有30例（30%）接受了HRT治疗（优势比为3.9；P<0.0005）。基于这项研究的结果，我们认为使用HRT可能会促使易患癌症的病变发生。这表明接受HRT治疗的患者需要通过检查和乳房X光检查进行密切监测。
