Petrov V I, Grigorév I A, Gorbunov S G
Eksp Klin Farmakol. 1997 May-Jun;60(3):6-8.
It was established that propranolol in a daily dose of 2 mg/kg causes disturbance of behavior of rats with arterial hypertension in the open field, deteriorates retention of memory traces in passive avoidance paradigm, and leads to the development of depression in the test for zoosocial interrelation. Administration of nootropic piracetam (200 kg/mg/24 h). as well as the original compounds ACP-94 (20 mg/kg/24 h) and PIR-87--6-0 (50-mg/kg/24 h) facilitates the correction of negative changes in the behavior and memory of hypertensive rats.
已确定，每日剂量为2mg/kg的普萘洛尔会导致动脉高血压大鼠在旷场实验中的行为紊乱，在被动回避范式中损害记忆痕迹的保留，并在社会关系测试中导致抑郁的发展。给予促智药吡拉西坦（200mg/kg/24h），以及原始化合物ACP-94（20mg/kg/24h）和PIR-87-6-0（50mg/kg/24h）有助于纠正高血压大鼠行为和记忆方面的负面变化。
