Kain H L
Augenklinik der Universität Basel, Schweiz.
Klin Monbl Augenheilkd. 1997 May;210(5):274-88. doi: 10.1055/s-2008-1035053.
The therapy of infectious endophthalmitis remain a controversial issue because progression and suboptimal outcome occur despite bacteriologic cure of the intraocular infection. The irreversible tissue destruction during the inflammatory process may result largely from a secondary host inflammatory response. However, adjunctive treatment with immunosuppressive agents may interfere with the ability of the immune system to eliminate the microorganisms. We discuss diagnostic means, therapy and options of adjunctive immunosuppression in the therapy of infectious endophthalmitis. Furthermore, we report on our clinical experience in patients with endogenous and exogenous infectious bacterial and mycotic endophthalmitis with combined treatment using high doses of steroids.
感染性眼内炎的治疗仍然是一个有争议的问题，因为尽管眼内感染已得到细菌学治愈，但仍会出现病情进展和治疗效果欠佳的情况。炎症过程中不可逆的组织破坏可能主要是由宿主的继发性炎症反应导致的。然而，使用免疫抑制剂进行辅助治疗可能会干扰免疫系统清除微生物的能力。我们讨论了感染性眼内炎治疗中的诊断方法、治疗及辅助免疫抑制的选择。此外，我们报告了我们在患有内源性和外源性感染性细菌性及霉菌性眼内炎的患者中使用大剂量类固醇联合治疗的临床经验。
