Scheuplein R J
J Invest Dermatol. 1976 Jul;67(1):31-8. doi: 10.1111/1523-1747.ep12512478.
Two developments have greatly added to our knowledge of percutaneous absorption over the past quarter century: (1) proof that the entire stratum corneum is the effective barrier layer of the skin, and (2) the advent of highly sensitive analytical techniques. The first enabled us to measure permeation rates on excised skin and the second greatly extended the kinds of substances that could be studied in vivo and in vitro. The process of percutaneous absorption is beginning to be understood more quantitatively. New light has been shed on the elementary mechanisms of permeation, the site of diffusional resistance at the molecular level, the effect of specific functional groups on solute permeation, the role of skin appendages, and the effects of vehicles.
在过去的四分之一个世纪里，有两项进展极大地增进了我们对经皮吸收的了解：（1）证明整个角质层是皮肤的有效屏障层，以及（2）高灵敏度分析技术的出现。前者使我们能够测量离体皮肤的渗透速率，后者则极大地扩展了可在体内和体外研究的物质种类。经皮吸收过程正开始得到更定量的理解。关于渗透的基本机制、分子水平扩散阻力的部位、特定官能团对溶质渗透的影响、皮肤附属器的作用以及载体的影响等方面都有了新的认识。
