Meiser H, Schulz R
Institut für Pharmakologie, Toxikologie und Pharmazie, Tierärztliche Fakultät der Ludwig-Maximilians-Universität München.
Berl Munch Tierarztl Wochenschr. 1997 Jul-Aug;110(7-8):284-7.
A dachshund suffered from vomitus, anorexia, apathy, and anemia. A metal button consisting of brass (alloy of copper and zinc) was diagnosed in the stomach and was removed. Blood analysis revealed an elevated level of zinc (10.7 micrograms/ml) associated with a low copper concentration (0.02 microgram/ml). This apparently paradoxical finding of copper deficiency despite of copper exposition (brass button) caused us to determine the diaminoxidase activity in serum, representing an indicator for the copper accumulating ceruloplasmin. The enzyme activity was found to be decreased. The case study brings to mind the mutual interaction between zinc and copper. Apparently, a copper deficiency is not necessarily due to a reduced supply of copper. Moreover, as shown by further investigations, an attenuated diaminoxidase activity represents an important parameter to diagnose a copper deficient state.
一只腊肠犬出现呕吐、厌食、冷漠和贫血症状。诊断发现其胃内有一枚由黄铜（铜和锌的合金）制成的金属纽扣，并将其取出。血液分析显示锌水平升高（10.7微克/毫升），同时铜浓度降低（0.02微克/毫升）。尽管接触了铜（黄铜纽扣），却出现明显矛盾的铜缺乏现象，这促使我们测定血清中二胺氧化酶的活性，该酶是铜蓄积蛋白铜蓝蛋白的一个指标。结果发现该酶活性降低。该病例研究让人想到锌与铜之间的相互作用。显然，铜缺乏不一定是由于铜供应减少。此外，进一步研究表明，二胺氧化酶活性减弱是诊断铜缺乏状态的一个重要参数。
