Smith J B, Ingerman C M, Silver M J
J Lab Clin Med. 1976 Jul;88(1):167-72.
The formation of malondialdehyde, a metabolite of prostaglandin endoperoxides, has been studied in platelet-rich plasma. Small amounts were produced in response to ADP, epinephrine, or collagen and larger amounts in response to thrombin. Arachidonic acid induced platelets to produce large amounts of malondialdehyde. Malondialdehyde formation by platelets was prevented by aspirin or indomethacin. The measurement of malondialdehyde in platelet-rich plasma may be used as an indicator of platelet prostaglandin synthesis, and is simpler than the measurement of prostaglandins.
在富含血小板的血浆中，对前列腺素内过氧化物的代谢产物丙二醛的形成进行了研究。ADP、肾上腺素或胶原可诱导产生少量丙二醛，而凝血酶可诱导产生大量丙二醛。花生四烯酸可诱导血小板产生大量丙二醛。阿司匹林或吲哚美辛可抑制血小板形成丙二醛。测定富含血小板血浆中的丙二醛可作为血小板前列腺素合成的指标，且比测定前列腺素更简单。
