Tobelem G, Michel H, de la Baume H, Brechot C, Degos L, Schaison G
Nouv Presse Med. 1979 Nov 12;8(44):3649-52.
In two patients treated by heparin for thrombosis, thrombocytopenia under 10 000/cumm occured accompanied with bleeding cud recurrent thrombosis. The demonstration in the patients' serum of a factor inducing platelet aggregation and serotonin release in the presence of heparin suggests that the thrombocytopenia could be of immuno-allergic origin. In both cases, the discontinuation of heparin resulted in clinical and biological improvement. The rare cases of heparin-induced thrombocytopenia reported in the literature are discussed.
在两名因血栓形成接受肝素治疗的患者中，出现了血小板计数低于10000/立方毫米的血小板减少症，并伴有出血和复发性血栓形成。在患者血清中发现一种在肝素存在下可诱导血小板聚集和5-羟色胺释放的因子，提示血小板减少症可能源于免疫过敏。在这两例中，停用肝素后临床和生物学状况均得到改善。本文讨论了文献中报道的罕见的肝素诱导的血小板减少症病例。
