Bademosi O, Falase A O, Jaiyesimi F, Bademosi A
J Neurol Neurosurg Psychiatry. 1976 Apr;39(4):325-9. doi: 10.1136/jnnp.39.4.325.
Thirty-eight percent of patients with infective endocarditis (36 of 95) had neuropsychiatric manifestations. In 75% (27 of 36), these features were the major presenting picture. Fifteen patients (42%) presented with cerebrovascular lesions and seven (19%) with meningitis. Toxic encephalopathy (12.5%) was not uncommon. Other neurological syndromes seen included psychosis and spinal cord lesions. The mortality was high especially when the infective endocarditis was acute in onset. It is essential to search diligently for an underlying cardiac cause in patients who present with neuropsychiatric symptoms because treatment of the underlying pathology improves prognosis.
38%的感染性心内膜炎患者（95例中的36例）有神经精神症状。其中75%（36例中的27例）这些症状为主要临床表现。15例患者（42%）出现脑血管病变，7例（19%）出现脑膜炎。中毒性脑病并不少见（占12.5%）。还可见其他神经综合征，如精神病和脊髓病变。死亡率很高，尤其是感染性心内膜炎起病急时。对于出现神经精神症状的患者，必须认真查找潜在的心脏病因，因为针对潜在病理状况的治疗可改善预后。
