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常见的NAD(P)H醌氧化还原酶多态性患病率的种族差异及其对抗癌化疗的影响。

Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy.

作者信息

Kelsey K T, Ross D, Traver R D, Christiani D C, Zuo Z F, Spitz M R, Wang M, Xu X, Lee B K, Schwartz B S, Wiencke J K

机构信息

Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115, USA.

出版信息

Br J Cancer. 1997;76(7):852-4. doi: 10.1038/bjc.1997.474.

DOI:10.1038/bjc.1997.474
PMID:9328142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2228056/
Abstract

The NAD(P)H quinone oxidoreductase (NQO1:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use.

摘要

烟酰胺腺嘌呤二核苷酸磷酸（NAD(P)H）醌氧化还原酶（NQO1：EC 1.6.99.2）是一种重要的生物转化酶系统，已知它还能代谢重要的新型化疗化合物。最近发现，编码该酶的基因在人类中具有多态性。在此，我们描述了这种多态性的种族分布，并指出这可能对抗肿瘤药物的研发和使用产生影响。

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本文引用的文献

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A polymorphism in NAD(P)H:quinone oxidoreductase (NQO1): relationship of a homozygous mutation at position 609 of the NQO1 cDNA to NQO1 activity.NAD（P）H：醌氧化还原酶（NQO1）的多态性：NQO1 cDNA第609位纯合突变与NQO1活性的关系。
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NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.人结肠癌细胞中NAD(P)H:醌氧化还原酶基因表达：调节DT-黄递酶活性和丝裂霉素敏感性的一种突变的特征
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