Witcofski R L, Pizzarello D J
J Nucl Med. 1976 Aug;17(8):715-8.
The potential hazards from internally administered radionuclides used in nuclear medicine are usually compared with one another and with diagnostic x-rays on the basis of the absorbed dose in rads, with no regard to the dose rate of the radiation. This study compared the carcinogenic potential of a dose of 250 rads delivered at different dose rates to rat livers by x-ray, 113mIn, and 198Au. The chemical carcinogen N-2-fluorenyldiacetamide was administered after irradiation to reduce the latent period and increase the number of radiogenic liver tumors. No significant difference in tumor incidence was observed among groups of animals treated with either 198Au, 113mIn, or x-irradiation.
核医学中使用的体内给药放射性核素的潜在危害通常会相互比较，并与诊断性X射线基于拉德（辐射吸收剂量单位）的吸收剂量进行比较，而不考虑辐射的剂量率。本研究比较了以不同剂量率通过X射线、113m铟和198金给予大鼠肝脏250拉德剂量时的致癌潜力。照射后给予化学致癌物N-2-芴基二乙酰胺以缩短潜伏期并增加放射性肝肿瘤的数量。在用198金、113m铟或X射线照射处理的动物组之间未观察到肿瘤发生率有显著差异。
