Combs G F, Pesti G M
J Nutr. 1976 Jul;106(7):958-66. doi: 10.1093/jn/106.7.958.
Experiments were conducted to determine the nature of the effect of dietary ascorbic acid on selenium nutrition in the chick. Results showed that ascorbic acid resulted in increased activities of the selenium-containing enzyme glutathione peroxidase in plasma, accompanied by an apparent reduction in the dietary selenium requirement of the vitamin E-deficient chick. The ascorbic acid contents of plasma, liver, kidney and adrenals were not affected by selenium or vitamin E deficiencies, indicating that selenium-vitamin E deficient chicks are not rendered scrobutic. Absorption experiments using ligated duodenal loops or oral doses indicated that dietary ascorbic acid promoted the enteric absorption of selenium but did not affect the absorption of vitamin E. These results support the hypothesis previously reported that factors which inhibit the oxidation of dietary selenium promote its absorption and, perhaps, its post-absorptive utilization in metabolically active components of the cell.
进行了实验以确定日粮抗坏血酸对雏鸡硒营养影响的性质。结果表明，抗坏血酸导致血浆中含硒酶谷胱甘肽过氧化物酶的活性增加，同时维生素E缺乏的雏鸡对日粮硒的需求量明显减少。血浆、肝脏、肾脏和肾上腺中的抗坏血酸含量不受硒或维生素E缺乏的影响，这表明硒-维生素E缺乏的雏鸡不会患坏血病。使用结扎十二指肠袢或口服剂量的吸收实验表明，日粮抗坏血酸促进了硒的肠道吸收，但不影响维生素E的吸收。这些结果支持了先前报道的假设，即抑制日粮硒氧化的因素会促进其吸收，也许还会促进其在细胞代谢活性成分中的吸收后利用。
