Combs G F
J Nutr. 1976 Jul;106(7):967-75. doi: 10.1093/jn/106.7.967.
Experiments were conducted to determine the nature of the interaction of high levels of vitamin A and vitamin E-selenium nutrition in the chicken. Results showed that chicks were protected from the vitamin E-selenium deficiency disease exudative diathesis (ED) by a high dietary level of vitamin A (1.0 X 10(6) IU/kg) which moderately depressed growth. A greater concentration (1.5 X 10(6) IU/kg) of vitamin A in the diets of hens fed a low vitamin E diet hastened their depletion of plasma tocopherols and increased plasma glutathione peroxidase (GSH-px) activity. At hatching the progeny of vitamin A-fed hens were severely depleted of plasma tocopherols but had normal plasma GSH-px activities. They showed increased susceptibility to ED when fed selenium-deficient, vitamin E-free diets for 2 weeks. Absorption studies using ligated duodenal loops or oral doses indicated that high-level dietary vitamin A promoted the enteric absorption of selenium but interfered with the absorption of vitamin E. The dual nature of these effects was related to the ED-protective influence of vitamin A when fed to chicks, and the ED-stimulative influence on progeny when vitamin A was fed to dams.
开展了实验以确定鸡体内高水平维生素A与维生素E - 硒营养之间相互作用的性质。结果表明，高膳食水平的维生素A（1.0×10⁶国际单位/千克）可保护雏鸡免受维生素E - 硒缺乏疾病渗出性素质（ED）的影响，但会适度抑制生长。在喂食低维生素E日粮的母鸡日粮中添加更高浓度（1.5×10⁶国际单位/千克）的维生素A会加速其血浆生育酚的消耗，并增加血浆谷胱甘肽过氧化物酶（GSH - px）活性。在孵化时，喂食维生素A的母鸡的后代血浆生育酚严重缺乏，但血浆GSH - px活性正常。当它们喂食缺硒、无维生素E的日粮2周时，对ED的易感性增加。使用结扎十二指肠袢或口服剂量进行的吸收研究表明，高膳食水平的维生素A促进了硒的肠道吸收，但干扰了维生素E的吸收。这些影响的双重性质与给雏鸡喂食维生素A时其对ED的保护作用，以及给母鸡喂食维生素A时对后代的ED刺激作用有关。
