通过连接IgE受体诱导大鼠肥大细胞膜上的钙流
Induction of calcium flux across the rat mast cell membrane by bridging IgE receptors.
作者信息
Ishizaka T, Foreman J C, Sterk A R, Ishizaka K
出版信息
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5858-62. doi: 10.1073/pnas.76.11.5858.
Abstract
Rabbit antibody against IgE receptors or its F(ab')2 fragments induced an increase of 45Ca uptake into normal mast cells, and this process was accompanied by histamine release. Evidence was obtained that a substantial portion of 45Ca uptake was due to movement of calcium across the cell membrane. Neither 45Ca uptake nor histamine release was induced by Fab' monomer fragments of the antireceptor antibody. However, bridging of receptor-bound Fab' fragments by antirabbit IgG or bridging of receptor-bound IgE by anti-IgE induced an increase in 45Ca uptake. The results collectively indicate that crosslinking IgE receptors increases the membrane permeability of the mast cells toward calcium.
摘要
抗IgE受体的兔抗体或其F(ab')2片段可使正常肥大细胞对45Ca的摄取增加，且此过程伴有组胺释放。有证据表明，45Ca摄取的很大一部分是由于钙跨细胞膜的移动。抗受体抗体的Fab'单体片段既不诱导45Ca摄取，也不诱导组胺释放。然而，抗兔IgG使与受体结合的Fab'片段交联，或抗IgE使与受体结合的IgE交联，均可诱导45Ca摄取增加。这些结果共同表明，IgE受体交联可增加肥大细胞对钙的膜通透性。
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Induction of calcium flux across the rat mast cell membrane by bridging IgE receptors.通过连接IgE受体诱导大鼠肥大细胞膜上的钙流
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