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L-精氨酸——一氧化氮合成的底物——其在周围动脉疾病患者治疗中的有益作用:与安慰剂对比的初步结果

L-arginine--substrate for no synthesis--its beneficial effects in therapy of patients with peripheral arterial disease: comparison with placebo-preliminary results.

作者信息

Slawinski M, Grodzinska L, Kostka-Trabka E, Bieron K, Goszcz A, Gryglewski R J

出版信息

Acta Physiol Hung. 1996;84(4):457-8.

PMID:9328630
Abstract

Intravenous infusions of L-arginine (L-ARG) and placebo (saline) resulted in improvement of clinical assessments, statistically significant after L-ARG but not after saline. Results of laboratory estimations for platelet and fibrynolysis changed significantly following L-ARG infusions but not after infusions of placebo. These data indicate beneficial effects of L-ARG as a therapeutic agent in patients with peripheral arterial obliterative disease (PAOD). In these patients exogenous L-ARG can be converted to NO.

摘要

静脉输注L-精氨酸(L-ARG)和安慰剂(生理盐水)均使临床评估得到改善,L-ARG输注后具有统计学意义,而生理盐水输注后则无。L-ARG输注后血小板和纤维蛋白溶解的实验室评估结果发生显著变化,而安慰剂输注后则无。这些数据表明L-ARG作为治疗剂对周围动脉闭塞性疾病(PAOD)患者具有有益作用。在这些患者中,外源性L-ARG可转化为一氧化氮(NO)。

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