Identification of 10, 11-epoxide and other cyclobenzaprine metabolites isolated from rat urine.
作者信息
Belvedere G, Pantarotto C, Rovei V, Frigerio A
出版信息
J Pharm Sci. 1976 Jun;65(6):815-21. doi: 10.1002/jps.2600650606.
PMID:932964
Abstract
Cyclobenzaprine (40 mg/kg ip) was administered to rats, and six urinary metabolites of this drug were identified. They were the 10, 11-epoxide, the N -oxide, the desmethyl derivative, the hydroxylated and desmethylhydroxylated compounds, and the N-oxide hydroxylated at the 10- or 11-position. Mass spectrometric analysis confirmed their structures.
摘要
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