在给予普罗替林后，从大鼠尿液中分离出普罗替林的10, 11 - 环氧化物。
Isolation of 10, 11-epoxide of protriptyline in rat urine after protriptyline administration.
作者信息
Rovei V, Belvedere G, Pantarotto C, Frigerio A
出版信息
J Pharm Sci. 1976 Jun;65(6):810-5. doi: 10.1002/jps.2600650605.
PMID:932963
Abstract
The 10, 11-epoxide, 10-hydroxy, and 10, 11-dihydrodiol metabolites of protriptyline were identified in rat urine collected after the administration of 40 mg/kg ip of protriptyline. Mass spectrometric characterization confirmed the structure of these metabolites.
摘要
在腹腔注射40mg/kg丙咪嗪后收集的大鼠尿液中，鉴定出了丙咪嗪的10,11-环氧化物、10-羟基和10,11-二氢二醇代谢物。质谱表征证实了这些代谢物的结构。
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