以猪胃黏蛋白作为模型黏液系统的流变学评估

Rheological evaluation of hog gastric mucin as a model mucus system.

作者信息

Marriott C, Kellaway I W

出版信息

J Pharm Sci. 1976 Jun;65(6):828-32. doi: 10.1002/jps.2600650608.

Abstract

The rheological evaluation of preparations containing 10, 15, 20, and 25% powdered hog gastric mucin was carried out over the 13-48 degrees temperature range using rotational and creep viscometry. The preparations were almost viscous, and no elastic behavior was demonstrated. The addition of borate ions frequently produced a slight decrease in viscosity. Tetracycline hydrochloride decreased the viscosity of the 10 and 25% materials, although the addition of this compound to fresh gastric and bronchial mucous gels markedly increased viscosity. The model is, therefore, only suitable in limited circumstances as a basis for the evaluation of the effect of drugs on gastric mucus.

摘要

使用旋转粘度计和蠕变粘度计，在13至48摄氏度的温度范围内，对含有10%、15%、20%和25%猪胃黏膜粉的制剂进行了流变学评估。这些制剂几乎都是粘性的，未表现出弹性行为。硼酸盐离子的添加常常会使粘度略有降低。盐酸四环素降低了10%和25%制剂的粘度，尽管将该化合物添加到新鲜的胃和支气管黏液凝胶中会显著增加粘度。因此，该模型仅在有限的情况下适用于评估药物对胃黏液的影响。