Grund V R, Pollack E W, Hunninghake D B
J Pharmacol Exp Ther. 1976 Jun;197(3):662-8.
The effect of histamine on serum free fatty acid (FFA) and glycerol levels was examined in humans and dogs in vivo. By the end of a 15-minute infusion of histamine diphosphate (11 mug of histamine per min i.v.), FFA levels in six male human volunteers had risen from basal values of 424 +/- 41 (mean +/- S.E.M.) to 909 +/- 45 muEq/1, and glycerol levels had risen from 66 +/- 5.5 to 124 +/- 9.3 mumol/1. These effects in man were not blocked by diphenhydramine, an H1-receptor antagonist, but were entirely blocked by propranolol, a beta adrenergic antagonist. Similar infusions of histamine (11 mug/min i.v.) in six anesthetized dogs caused FFA levels to rise from 189 +/- 13 to 461 +/- 92 muEq/1 and glycerol levels to rise from 58 +/- 3.7 to 157 +/- 22.4 mumol/1. These effects in the dog were not blocked by diphenhydramine or by propranolol but were entirely blocked by metiamide, an H2-receptor antagonist. These observations illustrate that low levels of histamine in vivo can produce significant elevations of serum FFA and glycerol levels in both humans and dogs. These results further suggest that the action of histamine in humans is indirect whereas the effect in dogs may be due to a direct action of histamine at the H2-receptor in canine adipose tissue.
在人和狗体内研究了组胺对血清游离脂肪酸（FFA）和甘油水平的影响。在静脉输注二磷酸组胺（每分钟11微克组胺）15分钟结束时，6名男性人类志愿者的FFA水平从基础值424±41（平均值±标准误）升至909±45微当量/升，甘油水平从66±5.5升至124±9.3微摩尔/升。在人类中，这些作用未被H1受体拮抗剂苯海拉明阻断，但被β肾上腺素能拮抗剂普萘洛尔完全阻断。在6只麻醉的狗中进行类似的组胺输注（每分钟11微克静脉注射），导致FFA水平从189±13升至461±92微当量/升，甘油水平从58±3.7升至157±22.4微摩尔/升。在狗中，这些作用未被苯海拉明或普萘洛尔阻断，但被H2受体拮抗剂甲硫米特完全阻断。这些观察结果表明，体内低水平的组胺可使人和狗的血清FFA和甘油水平显著升高。这些结果进一步表明，组胺在人类中的作用是间接的，而在狗中的作用可能是由于组胺直接作用于犬脂肪组织中的H2受体。
