Kozłowski S, Kowalik-Borówka E, Nazar K, Falecka-Wieczorek I, Stephens D, Kaciuba-Uściłko H
Horm Metab Res. 1985 Jan;17(1):8-11. doi: 10.1055/s-2007-1013434.
To evaluate the contribution of catecholamines to the fasting-induced lipid mobilization prolonged or acute blockade of beta-adrenergic receptors with propranolol was applied in dogs during 72 hrs of food withdrawal. Propranolol given orally in a dose of 15 mg twice daily throughout the whole period of fasting failed to modify the increases in the plasma FFA and glycerol concentrations. The acute beta-adrenergic blockade due to i.v. injection of propranolol (0.5 mg/kg b.w.) caused marked decreases in the plasma glycerol concentration both in the dogs fasting for 24 h and 72 hrs, whereas the effects of propranolol on the plasma FFA concentration was found only in the early stage of fasting. Plasma catecholamine concentrations were enhanced significantly by the 72 hrs food withdrawal and neither prolonged nor acute propranolol administration modified significantly this effect. The fasting-induced decreases in the serum insulin concentration were more pronounced in dogs treated with propranolol. Results of this study indicate that catecholamines are involved in the control of lipolysis during short term starvation. However, under these conditions beta-adrenergic blockade did not impair FFA mobilization most probably due to an enhanced contribution of other hormones to the control of this process.
为评估儿茶酚胺在禁食诱导的脂质动员中的作用，在犬禁食72小时期间，用普萘洛尔对β-肾上腺素能受体进行长期或急性阻断。在整个禁食期间，每日两次口服剂量为15mg的普萘洛尔，未能改变血浆游离脂肪酸（FFA）和甘油浓度的升高。静脉注射普萘洛尔（0.5mg/kg体重）引起的急性β-肾上腺素能阻断，使禁食24小时和72小时的犬血浆甘油浓度显著降低，而普萘洛尔对血浆FFA浓度的影响仅在禁食早期发现。禁食72小时可显著提高血浆儿茶酚胺浓度，长期或急性给予普萘洛尔均未显著改变这一效应。在接受普萘洛尔治疗的犬中，禁食诱导的血清胰岛素浓度降低更为明显。本研究结果表明，儿茶酚胺参与短期饥饿期间的脂肪分解控制。然而，在这些条件下，β-肾上腺素能阻断并未损害FFA动员，这很可能是由于其他激素对该过程控制的贡献增加。
