Monno R, Marcuccio L, Valenza M A, Leone E, Bitetto C, Larocca A, Maggi P, Quarto M
Institute of Medical Microbiology, Clinic of Infectious Diseases and Institute of Hygiene, University of Bari, Bari, Italy.
Acta Microbiol Immunol Hung. 1997;44(2):165-71.
In addition to the activity against a number of retroviruses, azidothymidine (AZT) has antibacterial activity against many bacteria. The effect of AZT on 224 bacterial species, including 25 strains of Salmonella spp. isolated from HIV-positive patients, was tested. AZT had no activity against all the strains of tested Gram-positive bacteria and Pseudomonas species (MIC > 128 micrograms/ml), whereas a different activity against Enterobacteriaceae (MIC range, 128 to 0.06 micrograms/ml) was found. In particular 76% of Salmonella spp. isolated from HIV-positive patients showed MICs > 1 microgram/ml, whereas similar MICs value were found in 50% of the Salmonella strains isolated from HIV-negative subjects. In addition, strains of Salmonella isolated from stools were more resistant to AZT when compared to strains isolated from blood even if this difference was not statistically significant. No correlation was found between length of therapy and Salmonella resistance to AZT in HIV-positive patients and a low incidence of Salmonella relapses in subjects treated with AZT was observed. The possibility that AZT may have an ancillary benefit in controlling some bacterial infections in AIDS patients is discussed.
除了对多种逆转录病毒有活性外，叠氮胸苷（AZT）对许多细菌也有抗菌活性。测试了AZT对224种细菌的作用，包括从HIV阳性患者中分离出的25株沙门氏菌属菌株。AZT对所有测试的革兰氏阳性菌和假单胞菌属菌株均无活性（MIC>128微克/毫升），而对肠杆菌科细菌有不同活性（MIC范围为128至0.06微克/毫升）。特别是，从HIV阳性患者中分离出的76%的沙门氏菌属菌株显示MIC>1微克/毫升，而从HIV阴性受试者中分离出的50%的沙门氏菌菌株有相似的MIC值。此外，与从血液中分离出的菌株相比，从粪便中分离出的沙门氏菌菌株对AZT更具抗性，即使这种差异无统计学意义。在HIV阳性患者中，未发现治疗时间长短与沙门氏菌对AZT的耐药性之间存在相关性，并且观察到接受AZT治疗的受试者沙门氏菌复发率较低。讨论了AZT在控制艾滋病患者某些细菌感染方面可能具有辅助益处的可能性。
