Westerhof N, Sipkema P, Vis M A
Laboratory for Physiology, Institute for Cardiovascular Research (ICaR-VU), Amsterdam, The Netherlands.
Adv Exp Med Biol. 1997;430:111-21. doi: 10.1007/978-1-4615-5959-7_10.
We modeled the influence of cardiac contraction on maximally dilated coronary blood vessels, whether single or in juxtaposition, taking into account the nonlinear material properties of both the vascular wall and the myocardium. We calculated pressure-area relations of single, embedded coronary blood vessels, and used these relations to calculate diastolic and systolic coronary pressure-flow relations in a model of the coronary vasculature. The model shows that the change in myocardial material properties during contraction can explain the decrease in coronary vessel area and coronary flow generally observed in experiments. The model also shows that arterioles can be protected from the compressive action of the cardiac muscle by the presence of accompanying venules, which is favorable for coronary blood flow.
我们模拟了心脏收缩对最大扩张状态下的冠状动脉血管（无论是单个还是并列存在）的影响，同时考虑了血管壁和心肌的非线性材料特性。我们计算了单个嵌入式冠状动脉血管的压力-面积关系，并利用这些关系计算了冠状动脉血管模型中的舒张期和收缩期冠状动脉压力-流量关系。该模型表明，收缩过程中心肌材料特性的变化可以解释实验中普遍观察到的冠状动脉血管面积和冠状动脉血流量的减少。该模型还表明，伴行小静脉的存在可使小动脉免受心肌的压缩作用，这有利于冠状动脉血流。
