Bassingthwaighte J B
Department of Bioengineering, University of Washington, Seattle 98195-7962, USA.
Adv Exp Med Biol. 1997;430:325-39. doi: 10.1007/978-1-4615-5959-7_28.
The Physiome Project has the goal of providing the quantitative description of the integrated functions of the living organism. This is too large an undertaking to be begun all at once. What needs to be developed first are large comprehensive databases containing genomic, biochemical, anatomical and physiological information that can be searched and retrieved via the Internet. A more modest and achievable goal is the Cardiome Project, whose goal is to describe the functioning heart. Since it is impractical to develop this from the genetic and molecular level, we begin it as a multicenter collaborative effort at the level of the functioning organ. The work of Hunter, Noble, and others provides a central scheme, a description of the spread of excitation and contraction through an anatomically detailed cardiac model with fiber directions. This will be augmented by the additions of regional blood flows, substrate uptake and metabolism, and energy production and utilization in serving contraction and ionic balances. Later stages will involve cellular regulation and responses to interventions. The organization of such projects is by the assembling of components whose linkages one to another are first minimized and then augmented to improve the approximation to reality.
生理组计划的目标是对生物体的综合功能进行定量描述。这是一项过于庞大的事业，无法一蹴而就。首先需要开发的是大型综合数据库，其中包含基因组、生化、解剖和生理信息，这些信息可以通过互联网进行搜索和检索。一个较为适度且可实现的目标是心脏组计划，其目标是描述心脏的功能。由于从基因和分子层面开展这项工作不切实际，我们将其作为一项在功能器官层面的多中心合作努力来启动。亨特、诺布尔等人的工作提供了一个核心方案，即通过一个具有纤维方向的解剖学详细心脏模型来描述兴奋和收缩的传播。这将通过增加局部血流、底物摄取和代谢以及为收缩和离子平衡提供服务的能量产生和利用来加以扩充。后期阶段将涉及细胞调节和对干预的反应。此类项目的组织方式是通过组装组件，首先将这些组件之间的联系降至最低，然后再加以扩充，以提高对现实的近似程度。
