纤溶酶原激活剂、整合素以及细胞黏附与迁移的协同调节

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration.

作者信息

Chapman H A

机构信息

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

出版信息

Curr Opin Cell Biol. 1997 Oct;9(5):714-24. doi: 10.1016/s0955-0674(97)80126-3.

DOI:10.1016/s0955-0674(97)80126-3

PMID:9330876

Abstract

Cellular migration is critically dependent on an interplay between forces of attachment and detachment. Recent studies show that the serine protease urokinase and its major inhibitor and receptor regulate the adhesive properties of integrins, at least in part through initiation of cellular signals. These new functions for an old protease system imply intricate connections between proteolysis and adhesion that operate at the cell surface to regulate migration.

摘要

细胞迁移严重依赖于附着力和脱离力之间的相互作用。最近的研究表明，丝氨酸蛋白酶尿激酶及其主要抑制剂和受体至少部分地通过启动细胞信号来调节整合素的黏附特性。这个古老蛋白酶系统的这些新功能意味着蛋白水解和黏附之间存在复杂的联系，这些联系在细胞表面发挥作用以调节迁移。