Medcalf Robert L, Keragala Charithani B
Molecular Neurotrauma and Haemostasis, Australian Centre for Blood Diseases, Central Clinical School, Monash University, Victoria, Australia.
Hemasphere. 2021 Jun 1;5(6):e570. doi: 10.1097/HS9.0000000000000570. eCollection 2021 Jun.
The deposition and removal of fibrin has been the primary role of coagulation and fibrinolysis, respectively. There is also little doubt that these 2 enzyme cascades influence each other given they share the same serine protease family ancestry and changes to 1 arm of the hemostatic pathway would influence the other. The fibrinolytic system in particular has also been known for its capacity to clear various non-fibrin proteins and to activate other enzyme systems, including complement and the contact pathway. Furthermore, it can also convert a number of growth factors into their mature, active forms. More recent findings have extended the reach of this system even further. Here we will review some of these developments and also provide an account of the influence of individual players of the fibrinolytic (plasminogen activating) pathway in relation to physiological and pathophysiological events, including aging and metabolism.
纤维蛋白的沉积和清除分别是凝血和纤溶的主要作用。毫无疑问，这两个酶级联相互影响，因为它们有着相同的丝氨酸蛋白酶家族起源，而且止血途径中一个分支的变化会影响另一个分支。特别是纤溶系统，其清除各种非纤维蛋白以及激活包括补体和接触途径在内的其他酶系统的能力也广为人知。此外，它还能将多种生长因子转化为其成熟的活性形式。最近的研究结果进一步拓展了该系统的作用范围。在此，我们将回顾其中的一些进展，并阐述纤溶（纤溶酶原激活）途径中各个因子对生理和病理生理事件（包括衰老和代谢）的影响。
