Eberling J L, Roberts J A, Rapp P R, Tuszynski M H, Jagust W J
Center for Functional Imaging, Lawrence Berkeley Laboratory, University of California, Berkeley 94720, USA.
Neurobiol Aging. 1997 Jul-Aug;18(4):437-43. doi: 10.1016/s0197-4580(97)00040-7.
Positron emission tomography and the glucose metabolic tracer [18F]fluorodeoxyglucose were used to evaluate the relationship between regional cerebral metabolic rates for glucose (rCMRglc), age, and performance on a delayed response (DR) test of memory in the aged monkey. Eleven aged animals, 21-26-years old, were included in the analysis. Regional CMRglc, normalized to values for the entire brain, were determined for the dorsal prefrontal cortex, orbitofrontal cortex, hippocampus, and temporal cortex. The aged animals exhibited significant DR deficits relative to a cohort of normal young monkeys. Variability in DR performance among the aged subjects was significantly correlated with relative hippocampal rCMRglc, and chronological age was a reliable predictor of orbitofrontal rCMRglc ratios. This pattern of results suggests that DR impairments in the aged monkey may partly reflect age-related dysfunction distributed among multiple limbic system structures that participate in normal learning and memory. Overall, the findings support the use of positron emission tomography in efforts to define the relationship between cognitive performance, age, and brain physiology in nonhuman primates.
正电子发射断层扫描和葡萄糖代谢示踪剂[18F]氟脱氧葡萄糖被用于评估老年猴子大脑局部葡萄糖代谢率（rCMRglc）、年龄与延迟反应（DR）记忆测试表现之间的关系。分析纳入了11只21 - 26岁的老年动物。测定了背外侧前额叶皮质、眶额叶皮质、海马体和颞叶皮质的rCMRglc，并将其标准化为全脑的值。与一组正常的年轻猴子相比，老年动物表现出明显的DR缺陷。老年受试者中DR表现的变异性与海马体相对rCMRglc显著相关，而实际年龄是眶额叶rCMRglc比率的可靠预测指标。这种结果模式表明，老年猴子的DR损伤可能部分反映了与年龄相关的功能障碍，这种功能障碍分布在参与正常学习和记忆的多个边缘系统结构中。总体而言，这些发现支持在非人灵长类动物中使用正电子发射断层扫描来确定认知表现、年龄和脑生理学之间的关系。
