Wang J J, Mitchell P, Smith W
Department of Ophthalmology, University of Sydney, Australia.
Ophthalmology. 1997 Oct;104(10):1714-9. doi: 10.1016/s0161-6420(97)30075-x.
To determine whether an association exists between migraine headache history and open-angle glaucoma (OAG).
Population-based, cross-sectional study.
Subjects were 3654 people aged 49 or older; 82% of permanent residents from an area west of Sydney participated.
All participants underwent an interview and a detailed eye examination, including automated perimetry and stereo optic disc photography.
Open-angle glaucoma was diagnosed in subjects with matching typical glaucomatous visual field defects and pathologic optic disc cupping, independent of intraocular pressure level. The diagnosis of migraine history (typical or nontypical) was based on participant responses to specific questions, consistent with International Headache Society criteria.
Open-angle glaucoma prevalence increased exponentially with age, with rates of 0.4%, 1.3%, 4.7%, and 11.4% among persons aged less than 60 years, between 60 and 69 years, between 70 and 79 years, and 80 years or older, respectively. The frequency of reporting a past history of typical migraine headache declined with increasing age, with rates of 23.1%, 16.2%, 12.8%, and 10.4% for corresponding age groups. For all age groups combined, there was no significant association between typical migraine headache and OAG (odds ratio [OR], 1.3; 95% confidence interval [CI], 0.8-2.2), after multivariate adjustment. However, after stratifying into 10-year age groups, increased odds for OAG were found for people giving a history of typical migraine headache and aged 70-79 years (OR, 2.5; 95% CI 1.2-5.2), after adjusting for variables found associated with glaucoma. This association was marginally stronger for high-pressure OAG cases (OR, 2.7; 95% CI, 1.1-5.6).
These data suggest the possibility of an association between history of typical migraine headache and OAG, which could be modified by age.
确定偏头痛病史与开角型青光眼（OAG）之间是否存在关联。
基于人群的横断面研究。
受试者为3654名49岁及以上的人群；悉尼以西一个地区82%的常住人口参与了研究。
所有参与者均接受了访谈和详细的眼科检查，包括自动视野计检查和立体视盘照相。
在具有匹配的典型青光眼性视野缺损和病理性视盘凹陷的受试者中诊断开角型青光眼，不受眼压水平影响。偏头痛病史（典型或非典型）的诊断基于参与者对特定问题的回答，符合国际头痛协会的标准。
开角型青光眼患病率随年龄呈指数增长，年龄小于60岁、60至69岁、70至79岁以及80岁及以上人群的患病率分别为0.4%、1.3%、4.7%和11.4%。报告有典型偏头痛病史的频率随年龄增长而下降，相应年龄组的频率分别为23.1%、16.2%、12.8%和10.4%。在多变量调整后，对于所有年龄组合并分析，典型偏头痛头痛与开角型青光眼之间无显著关联（优势比[OR]为1.3；95%置信区间[CI]为0.8 - 2.2）。然而，在按10岁年龄组分层后，在调整了与青光眼相关的变量后，70至79岁有典型偏头痛病史的人群患开角型青光眼的几率增加（OR为2.5；95% CI为1.2 - 5.2）。这种关联在高眼压性开角型青光眼病例中略强（OR为2.7；95% CI为1.1 - 5.6）。
这些数据表明典型偏头痛病史与开角型青光眼之间可能存在关联，且这种关联可能受年龄影响。
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