Wooliscroft Jeffrey, Akram Rubeel, Zuberi Hafsa, Tong Betty, Gu Jane, Hurd Aaron, Kooner Karanjit
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Department of Ophthalmology, Veteran Affairs North Texas Health Care System Medical Center, Dallas, TX, USA.
Clin Ophthalmol. 2022 Jun 10;16:1925-1932. doi: 10.2147/OPTH.S360719. eCollection 2022.
PURPOSE/RELEVANCE: To determine the influence of hypertension (HTN), type 2 diabetes (DM2), migraine, and obstructive sleep apnea (OSA) on the onset of primary open-angle glaucoma (POAG) to enhance predictive accuracy.
In this cross-sectional study, data for 389 eligible patients with POAG were collected through medical records review and phone surveys. All data were assessed collectively using stepwise multiple regression analysis to determine the relative contribution to age at POAG diagnosis. We used the following groups, based on age at diagnosis, HTN for patients with or without DM2 (model 1), HTN for patients with DM2 (model 2), DM2 for patients with or without HTN (model 3), and DM2 for patients with HTN (model 4).
In model 1, age at HTN diagnosis was associated with age at POAG diagnosis (β = 0.14; 95% CI, 0.01-0.26, p = 0.04). In model 2, age at HTN diagnosis was not associated with age at POAG diagnosis (p > 0.05). In model 3, age at DM2 diagnosis was associated with age at POAG diagnosis (β = 0.37; 95% CI 0.16-0.58, p = 0.001). In model 4, age at DM2 diagnosis was associated with age at POAG diagnosis (β = 0.40; 95% CI 0.00-0.15, p = 0.003). Asian race/ethnicity was associated with early onset of POAG in model 3 (β = -6.44; 95% CI -12.34-0.54, p = 0.033). OSA and migraine did not influence the onset of POAG.
Our study found that the diagnosis of DM2 and HTN at an earlier age is associated with the early onset of POAG.
目的/相关性：确定高血压（HTN）、2型糖尿病（DM2）、偏头痛和阻塞性睡眠呼吸暂停（OSA）对原发性开角型青光眼（POAG）发病的影响，以提高预测准确性。
在这项横断面研究中，通过病历审查和电话调查收集了389例符合条件的POAG患者的数据。使用逐步多元回归分析对所有数据进行综合评估，以确定对POAG诊断年龄的相对贡献。我们根据诊断年龄将患者分为以下几组：患有或未患有DM2的HTN患者（模型1）、患有DM2的HTN患者（模型2）、患有或未患有HTN的DM2患者（模型3）以及患有HTN的DM2患者（模型4）。
在模型1中，HTN诊断年龄与POAG诊断年龄相关（β = 0.14；95%置信区间，0.01 - 0.26，p = 0.04）。在模型2中，HTN诊断年龄与POAG诊断年龄无关（p > 0.05）。在模型3中，DM2诊断年龄与POAG诊断年龄相关（β = 0.37；95%置信区间0.16 - 0.58，p = 0.001）。在模型4中，DM2诊断年龄与POAG诊断年龄相关（β = 0.40；95%置信区间0.00 - 0.15，p = 0.003）。在模型3中，亚洲种族与POAG的早发相关（β = -6.44；95%置信区间 -12.34 - 0.54，p = 0.033）。OSA和偏头痛不影响POAG的发病。
我们的研究发现，较早诊断DM2和HTN与POAG的早发相关。
