CTLA4-Ig prolongs survival of microencapsulated neonatal porcine islet xenografts in diabetic NOD mice.

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作者信息

Weber C J, Hagler M K, Chryssochoos J T, Kapp J A, Korbutt G S, Rajotte R V, Linsley P S

机构信息

Department of Surgery, Bristol Myers-Squibb, Seattle, WA, USA.

出版信息

Cell Transplant. 1997 Sep-Oct;6(5):505-8. doi: 10.1177/096368979700600510.

DOI:10.1177/096368979700600510

PMID:9331502

Abstract

摘要

相似文献

CTLA4-Ig prolongs survival of microencapsulated neonatal porcine islet xenografts in diabetic NOD mice.

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Proliferative and cytokine responses in CTLA4-Ig-treated diabetic NOD mice transplanted with microencapsulated neonatal porcine ICCs.在移植了微囊化新生猪胰岛细胞簇（ICCs）的CTLA4-Ig处理的糖尿病非肥胖糖尿病（NOD）小鼠中的增殖和细胞因子反应

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Immunotherapy with nondepleting anti-CD4 monoclonal antibodies but not CD28 antagonists protects islet graft in spontaneously diabetic nod mice from autoimmune destruction and allogeneic and xenogeneic graft rejection.使用非耗竭性抗CD4单克隆抗体而非CD28拮抗剂进行免疫治疗，可保护自发性糖尿病nod小鼠的胰岛移植免受自身免疫破坏以及同种异体和异种移植排斥。

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Prevention of T-cell activation by rhCTLA4-Ig and anti-CD40L monoclonal antibody results in indefinite islet allograft survival.重组人CTLA4-Ig和抗CD40L单克隆抗体对T细胞激活的抑制作用可使胰岛移植长期存活。

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Effects of virus expressing CTLA4-IG and IL1-RA on islet xenografts.表达CTLA4-IG和IL-1RA的病毒对胰岛异种移植的影响。

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Cyclophosphamide, but not CTLA4Ig, prolongs survival of fetal pig islet grafts in anti-T cell monoclonal antibody-treated NOD mice.环磷酰胺而非CTLA4Ig可延长经抗T细胞单克隆抗体治疗的NOD小鼠体内胎猪胰岛移植物的存活时间。

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Blockade of the CD28 and CD40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice.阻断CD28和CD40通路可使小鼠接受猪和大鼠胰岛异种移植，但不能接受大鼠心脏移植。

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In vitro platform establishes antigen-specific CD8 T cell cytotoxicity to encapsulated cells via indirect antigen recognition.体外平台通过间接抗原识别建立针对包被细胞的抗原特异性 CD8 T 细胞细胞毒性。

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Modulating co-stimulation.调节共刺激

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