Yoshikawa M, Shimada H, Horikawa S, Murakami T, Shimoda H, Yamahara J, Matsuda H
Kyoto Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo). 1997 Sep;45(9):1498-503. doi: 10.1248/cpb.45.1498.
The methanolic extract of the underground part of Rhodiola sacra (PRAIN ex HAMET) S. H. Fu was found to show inhibitory activity on the histamine release from rat peritoneal exudate cells induced by an antigen-antibody reaction. From the methanolic extract with the inhibitory activity on histamine release, a new cyanoglycoside called rhodiocyanoside D and two new monoterpene glycosides called sacranosides A and B were isolated, together with eight known compounds, rhodiocyanoside A, heterodendrin, lotaustralin, rhodioloside, 2-phenylethyl alpha-L-arabinopyranosyl(1-->6)-beta-D-glucopyranoside, 2-methyl-3-buten-2-yl beta-D-glucopyranoside, kenposide A, and rhodiooctanoside. The structures of new compounds were determined on the basis of chemical and physicochemical evidence, which included the synthesis of sacranoside A from (-)-myrtenol. All major chemical constituents from R. sacra inhibited the histamine release and, among them, lotaustralin and rhodiooctanoside were found to show potent inhibitory activity.
研究发现，圣地红景天（Rhodiola sacra (PRAIN ex HAMET) S. H. Fu）地下部分的甲醇提取物对由抗原-抗体反应诱导的大鼠腹腔渗出细胞组胺释放具有抑制活性。从具有组胺释放抑制活性的甲醇提取物中，分离出一种名为红景天氰苷D的新氰苷以及两种名为圣地糖苷A和B的新单萜糖苷，同时还分离出8种已知化合物，即红景天氰苷A、异黄酮苷、洛托皂苷、红景天苷、2-苯乙基α-L-阿拉伯吡喃糖基(1→6)-β-D-葡萄糖吡喃糖苷、2-甲基-3-丁烯-2-基β-D-葡萄糖吡喃糖苷、肯波苷A和红景天辛糖苷。新化合物的结构是根据化学和物理化学证据确定的，其中包括由(-)-桃金娘烯醇合成圣地糖苷A。圣地红景天的所有主要化学成分均抑制组胺释放，其中，洛托皂苷和红景天辛糖苷显示出较强的抑制活性。
