Dorman B W, Schmidt J D
J Urol. 1976 Jul;116(1):51-3. doi: 10.1016/s0022-5347(17)58671-1.
We present 4 patients seen in the last 5 years who had taken thioridazine (Mellaril) prior to development of priapism. One of the 4 patients suffered penile trauma while taking the phenothiazine drug and this is another possible etiologic factor in that case. No underlying urologic or hematologic disorders were present. All patients were treated by corporeal aspiration and corpus cavernosum-corpus spongiosum shunts. The mechanism of phenothiazine=induced priapism is hypothesized as being related to its peripheral adrenergic blockade, perhaps directly blocking the sympathetic impulse for detumescence, although a central nervous system effect must be considered as well. Lastly there exists the possibility of coincidence since phenothiazine treatment is becoming more common and was unrelated to the condition in an additional 6 patients with priapism seen during the same period.
我们介绍了过去5年中见到的4例在发生阴茎异常勃起之前服用过硫利达嗪（美立廉）的患者。4例患者中有1例在服用吩噻嗪类药物时遭受了阴茎创伤，这是该病例中另一个可能的病因。所有患者均无潜在的泌尿系统或血液系统疾病。所有患者均接受了阴茎海绵体抽吸和阴茎海绵体-尿道海绵体分流术治疗。吩噻嗪类药物所致阴茎异常勃起的机制被推测与其外周肾上腺素能阻滞有关，可能直接阻断了阴茎疲软的交感神经冲动，不过也必须考虑中枢神经系统的作用。最后，由于吩噻嗪类药物治疗越来越普遍，同期见到的另外6例阴茎异常勃起患者与该药物无关，因此存在巧合的可能性。
