Hurtt A E, Smith M O
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA.
J Am Vet Med Assoc. 1997 Oct 1;211(7):866-7.
To examine the effects that iatrogenic blood contamination would have on total protein concentration and nucleated cell count in CSF from clinically normal dogs and dogs with neurologic disease.
Case-control study.
53 dogs confirmed to have neurologic disease and 21 clinically normal dogs.
CSF samples were obtained from the cerebellomedullary cistern or the lumbar portion of the subarachnoid space. Red blood and nucleated cell counts were determined, and protein concentration was measured.
RBC count was not significantly correlated with nucleated cell count or protein concentration in clinically normal dogs or dogs with neurologic disease.
High CSF nucleated cell counts and protein concentrations are indicative of neurologic disease, even if samples contain moderate amounts of blood contamination.
研究医源性血液污染对临床正常犬和患有神经疾病犬脑脊液中总蛋白浓度和有核细胞计数的影响。
病例对照研究。
53只确诊患有神经疾病的犬和21只临床正常的犬。
从枕大池或蛛网膜下腔腰椎部位采集脑脊液样本。测定红细胞和有核细胞计数，并测量蛋白质浓度。
临床正常犬或患有神经疾病的犬中，红细胞计数与有核细胞计数或蛋白质浓度均无显著相关性。
即使样本含有中等量的血液污染，脑脊液中有核细胞计数和蛋白质浓度升高仍提示神经疾病。
