Hoffman T L, MacGregor R R, Burger H, Mick R, Doms R W, Collman R G
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104-6060, USA.
J Infect Dis. 1997 Oct;176(4):1093-6. doi: 10.1086/516519.
Persons who are homozygous for the delta32 polymorphism of the CCR5 chemokine receptor gene are highly protected against human immunodeficiency virus type 1 (HIV-1) infection. Previous studies described 54 HIV-1-discordant couples in whom no virus transmission occurred despite extensive sexual contact. The possible role of the delta32 polymorphism in the lack of HIV-1 transmission between these partners was studied. No participants were homozygous for the delta32 allele, but the proportion that was heterozygous was higher among HIV-1-seronegative than HIV-1-seropositive partners (28% vs. 11%, P = .05). This association was seen in heterosexual couples (P = .03) but not in homosexual couples (P = .74). Among white persons, who are most likely to carry the delta32 allele, 38.9% of HIV-1-uninfected and 5.6% of HIV-1-infected heterosexual partners were heterozygous (P = .04). These data are consistent with a possible association between the heterozygous delta32 genotype in heterosexual sex partners and partial protection against HIV-1 infection, and they emphasize the importance of analyzing different risk groups in studies of host factors that influence infection.
CCR5趋化因子受体基因delta32多态性的纯合子个体对1型人类免疫缺陷病毒（HIV-1）感染具有高度抵抗力。此前的研究描述了54对HIV-1血清学不一致的伴侣，尽管他们有广泛的性接触，但并未发生病毒传播。研究了delta32多态性在这些伴侣之间缺乏HIV-1传播中可能发挥的作用。没有参与者是delta32等位基因的纯合子，但在HIV-1血清学阴性的伴侣中，杂合子的比例高于HIV-1血清学阳性的伴侣（28%对11%，P = 0.05）。这种关联在异性恋伴侣中可见（P = 0.03），但在同性恋伴侣中未见（P = 0.74）。在最有可能携带delta32等位基因的白人中，38.9%未感染HIV-1的异性恋伴侣和5.6%感染HIV-1的异性恋伴侣是杂合子（P = 0.04）。这些数据与异性恋性伴侣中的delta32杂合基因型与部分抵抗HIV-1感染之间可能存在关联相一致，并且强调了在研究影响感染的宿主因素时分析不同风险组的重要性。
