Calzetti C, Magnani G, Confalonieri D, Capelli A, Moneta S, Scognamiglio P, Fiaccadori F
Divisione di Malattie Infettive, Azienda Ospedaliera di Parma.
Ann Ital Med Int. 1997 Apr-Jun;12(2):63-6.
Up to the present, pancreatic complications due to cryptosporidium parvum infection have been described only in a few patients with acquired immunodeficiency syndrome (AIDS). We report our experience with 3 subjects with AIDS who presented with acute or chronic pancreatitis related to cryptosporidiosis. All 3 patients had abdominal pain resistant to analgesics, increased serum amylase and abnormalities at both sonography and computed tomography. Endoscopic retrograde cholangiopancreotography revealed papillary stenosis in all patients; one patient also had stenosis of the Wirsung duct. Cryptosporidium was found in both bile and stool samples in all patients, while viral cultures were negative, even in the 2 patients who had cytomegalovirus retinitis. Endoscopic sphincterotomy temporally relieved abdominal pain in all patients, but did not prevent either acute or recurrent pancreatic inflammation. Several antibiotic therapeutic protocols were ineffective against the parasite.
迄今为止，仅在少数获得性免疫缺陷综合征（AIDS）患者中描述过由微小隐孢子虫感染引起的胰腺并发症。我们报告了3例AIDS患者的经验，这些患者表现为与隐孢子虫病相关的急性或慢性胰腺炎。所有3例患者均有对镇痛药无效的腹痛、血清淀粉酶升高以及超声和计算机断层扫描异常。内镜逆行胰胆管造影显示所有患者均有乳头狭窄；1例患者还存在主胰管狭窄。所有患者的胆汁和粪便样本中均发现隐孢子虫，而病毒培养均为阴性，即使是2例患有巨细胞病毒性视网膜炎的患者也是如此。内镜下括约肌切开术暂时缓解了所有患者的腹痛，但未能预防急性或复发性胰腺炎症。几种抗生素治疗方案对该寄生虫均无效。
