Kiersztejn M, Wiecek A, Kokot F, Kuczera M
Katedry i Kliniki Nefrologii Slaskiej Akademii Medycznej w Katowicach.32
Pol Arch Med Wewn. 1997 Mar;97(3):211-5.
Assessment of plasma renin activity (PRA) in renal vein blood is used in the diagnosis of unilateral renovascular hypertension (URVH). Recently also other markers of renal ischaemia (atrial natriuretic peptide, adrenalin, nonadrenaline and dopamine) have been described. The present study aimed to assess renal handling of vasopressin (AVP) by the ischaemic kidney in patients with URVH. In 16 patients with URVH, PRA and AVP were estimated in renal vein blood of the ischemic (IK) and non-ischemic kidney (NK), in arterial blood (A) and in blood samples withdrawn from the inferior vena cava (VCI) below the orifices of the renal veins. In contrast to PRA no significant difference between plasma levels of AVP in renal vein blood of the ischaemic and non-ischaemic kidney was noticed (4.8 +/- 0.9 pg/ml vs 5.1 +/- 0.8 pg/ml respectively).
Chronic hypoperfusion of the kidney does not influence renal handling of AVP in patients with URVH. Thus assessment of AVP in renal vein blood in these patients is deprived of diagnostic value.
肾静脉血中血浆肾素活性（PRA）的评估用于诊断单侧肾血管性高血压（URVH）。最近还描述了其他肾缺血标志物（心房利钠肽、肾上腺素、去甲肾上腺素和多巴胺）。本研究旨在评估URVH患者缺血肾对血管加压素（AVP）的处理情况。对16例URVH患者，在缺血肾（IK）和非缺血肾（NK）的肾静脉血、动脉血（A）以及从肾静脉开口下方的下腔静脉（VCI）采集的血样中，测定PRA和AVP。与PRA不同，缺血肾和非缺血肾肾静脉血中AVP的血浆水平未发现显著差异（分别为4.8±0.9 pg/ml和5.1±0.8 pg/ml）。
在URVH患者中，肾脏的慢性低灌注不影响肾脏对AVP的处理。因此，对这些患者肾静脉血中AVP的评估缺乏诊断价值。
